ChloroquineV1, Main, Exploration, bibRecord, 000E70

The Effect of Tumor Microenvironment on Autophagy and Sensitivity to Targeted Therapy in EGFR-Mutated Lung Adenocarcinoma.

Identifieur interne : 000E70 ( Main/Exploration ); précédent : 000E69; suivant : 000E71

The Effect of Tumor Microenvironment on Autophagy and Sensitivity to Targeted Therapy in EGFR-Mutated Lung Adenocarcinoma.

Auteurs : Yuan-Yuan Li ; Sze-Kwan Lam ; Chun-Yan Zheng ; James Chung-Man Ho

Source :

Journal of Cancer [ 1837-9664 ] ; 2015.

RBID : pubmed:25767609

Abstract

Lung cancer is the top cancer killer worldwide. Tyrosine kinase inhibitors (TKIs), for example erlotinib, are commonly used to target epidermal growth factor receptor (EGFR)-mutated lung adenocarcinoma (ADC). Autophagy is a cellular response to stress, serving as a protective mechanism during anticancer therapy. The tumor microenvironment (TME) is composed of non-tumor cells that include fibroblasts. Our study aimed to investigate the effect of TME on autophagy and TKI sensitivity. Following cell sorting after direct co-culturing, autophagy and cytokine production were observed in both HCC827 and MRC-5 cells. The synergistic combination of erlotinib and chloroquine (autophagy inhibitor) was observed under TME. Tumor growth was significantly suppressed with combined erlotinib/chloroquine compared with erlotinib in HCC827 xenografts.

DOI: 10.7150/jca.11187
PubMed: 25767609

Affiliations:

Le document en format XML

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<author><name sortKey="Li, Yuan Yuan" sort="Li, Yuan Yuan" uniqKey="Li Y" first="Yuan-Yuan" last="Li">Yuan-Yuan Li</name>
<affiliation><nlm:affiliation>Division of Respiratory Medicine, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR.</nlm:affiliation>
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<author><name sortKey="Lam, Sze Kwan" sort="Lam, Sze Kwan" uniqKey="Lam S" first="Sze-Kwan" last="Lam">Sze-Kwan Lam</name>
<affiliation><nlm:affiliation>Division of Respiratory Medicine, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR.</nlm:affiliation>
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<author><name sortKey="Zheng, Chun Yan" sort="Zheng, Chun Yan" uniqKey="Zheng C" first="Chun-Yan" last="Zheng">Chun-Yan Zheng</name>
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<author><name sortKey="Ho, James Chung Man" sort="Ho, James Chung Man" uniqKey="Ho J" first="James Chung-Man" last="Ho">James Chung-Man Ho</name>
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<series><title level="j">Journal of Cancer</title>
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<front><div type="abstract" xml:lang="en">Lung cancer is the top cancer killer worldwide. Tyrosine kinase inhibitors (TKIs), for example erlotinib, are commonly used to target epidermal growth factor receptor (EGFR)-mutated lung adenocarcinoma (ADC). Autophagy is a cellular response to stress, serving as a protective mechanism during anticancer therapy. The tumor microenvironment (TME) is composed of non-tumor cells that include fibroblasts. Our study aimed to investigate the effect of TME on autophagy and TKI sensitivity. Following cell sorting after direct co-culturing, autophagy and cytokine production were observed in both HCC827 and MRC-5 cells. The synergistic combination of erlotinib and chloroquine (autophagy inhibitor) was observed under TME. Tumor growth was significantly suppressed with combined erlotinib/chloroquine compared with erlotinib in HCC827 xenografts. </div>
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<name sortKey="Li, Yuan Yuan" sort="Li, Yuan Yuan" uniqKey="Li Y" first="Yuan-Yuan" last="Li">Yuan-Yuan Li</name>
<name sortKey="Zheng, Chun Yan" sort="Zheng, Chun Yan" uniqKey="Zheng C" first="Chun-Yan" last="Zheng">Chun-Yan Zheng</name>
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The Effect of Tumor Microenvironment on Autophagy and Sensitivity to Targeted Therapy in EGFR-Mutated Lung Adenocarcinoma.

The Effect of Tumor Microenvironment on Autophagy and Sensitivity to Targeted Therapy in EGFR-Mutated Lung Adenocarcinoma.

Source :

Abstract

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Le document en format XML

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Pour générer des pages wiki

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